Glycoclusters
WebAug 14, 2024 · The glycoclusters were efficiently obtained from per-azido α, β and γ-CD derivatives and propargyl glycosides using click-chemistry under microwave irradiation. The methodology was successfully applied to various protected and non-protected propargylated monosaccharides, including both O- and S-glycosides, giving clear evidence of its ... WebHerein, we report the synthesis of 18 oligonucleotide pentofuranose-centered or mannitol-centered glycoclusters leading to tri-, penta- or decavalent clusters with different topologies. The linker arm length between the core and the carbohydrate epitope was also varied leading to 9 galactoclusters targeting LecA and 9 fucoclusters targeting ...
Glycoclusters
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WebApr 12, 2024 · Former group member Serena Riela, Associate Professor in the Department of Biological Chemical and Pharmaceutical Sciences and Technologies (STEBICEF) of the University of Palermo from 2024, has recently been appointed to the position of Full Professor in the Department of Chemical Science of the University of Catania.Serena’s … WebGlycopolymer is synthetic polymer with pendant carbohydrates. [1] Glycopolymers play an important role in many biological recognition events such as cell–cell adhesion, …
WebMar 7, 2011 · The glycoclusters obtained were evaluated as ligands of PA-IL and for their potential for competing with its binding to glycosylated surfaces. The affinities measured by hemagglutination inhibition assay (HIA), enzyme-linked lectin assay (ELLA), and surface plasmon resonance (SPR) displayed a significant "glycoside cluster effect" with up to a ... WebSep 10, 2024 · A series of 1,2,4-triazole derivatives were synthesized and assigned as potential anti-tuberculosis substances and the obtained results clearly confirmed the antituberculosis potential of compound C4, which turned out to be the most active against Mycobacterium H37Ra.
Webglycocluster (pl. glycoclusters) A cluster of glycans proposed as a means of drug delivery WebOct 18, 2014 · In the process of oligosaccharides drug screening, the fractal dimension of receptor and designed oligosaccharides or glycoclusters can be calculated respectively. The oligosaccharides with fractal dimension close to that of target receptor should then take priority compared with others, to get the drug molecules with latent activity.
WebFeb 24, 2011 · In these glycoclusters, the flexible nature of the polymer main chain permits its structural rearrangement and therefore, these glycoclusters take unique cylindrical structures composed of hydrophobic cores and hydrophilic surfaces [47-49]. As a result, hydrophobic moieties interact with each other in an intrapolymer fashion, and …
WebSelf-Assembled 2D Glycoclusters for the Targeted Delivery of Theranostic Agents to Triple-Negative Breast Cancer Cells Xi-Le Hu Key … o365 onboarding portalWebMay 21, 2013 · The anionic calixarenes para-sulphonatocalix[4]arene and 1,3-di-Ophosphonatocalix[ 4]arene, have been used to cap silver nanoparticles. The binding of these functional particles with regard to various serum albumins (bovine serum albumin, human serum albumin, porcine serum albumin and sheep serum albumin) has been … o365 onboarding tcsWebDec 7, 2024 · The AIE-based glycoclusters were successfully used for (1) the fluorogenic detection of functionally diverse glycosidases including galactosidase, glucosidase and fucosidase, (2) the fluorescence imaging of the endogenous glycosidase activities in healthy and cancer cells, and during cell senescence, and (3) glycosidase-activated, long-term ... maheshwari pharmaceuticals india limitedWebNov 11, 2024 · To overcome this problem, tetraphenylethylene (TPE) based glycoclusters were used to self-assemble with these DM probes to obtain supramolecular water-soluble glyco-dots. This self-assembly strategy enhanced the fluorescence intensity, leading to an enhanced selectivity and activity of the resulting glyco-dot comparing to DM probes alone … o365 online archive licenseWebMar 29, 2024 · Here, the synthesis and glycosidase inhibition properties of the two first known 3-ethyloctahydro-1H-indole-4,5,6-triols are reported. This study shows the transformation of d-glucose into polyhydroxylated 1-(2-nitrocyclohexane) acetaldehydes, followed by a protocol involving the formation of the azacyclopentane ring. Results of … o365 office sign inWebAug 21, 2024 · The results showed a favorable effect due to the presence of the undecyl chains in terms of affinity. Surprisingly, the β-S-AllNAc octavalent compound showed the highest affinity among the evaluated glycoclusters, showing for the first time that WGA interacts with β-AllNAc-bearing ligands. Molecular docking studies of β-AllNAc with WGA … o365 online archive size limitWebSupercluster. A supercluster is a large group of smaller galaxy clusters or galaxy groups; [1] they are among the largest known structures in the universe. The Milky Way is part of the Local Group galaxy group (which … maheshwari public school ajmer