Glycolysis dc sting
WebJan 11, 2024 · Macrophages rapidly reprogram their metabolic state to facilitate inflammation, resolution, and effector functions [ 4, 5 ]. The metabolic reprogramming of … WebMechanistically, STING agonists activated STAT3 and promoted glycolysis in IECs. Inhibition of STAT3 pathway and glycolysis suppressed STING-induced REG3γ …
Glycolysis dc sting
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Web2 China. Phone: 086-021-22200000-1511; Email: [email protected]. Or to: Xin-Gang Cui, Department of Urology, Xinhua Hospital, Shanghai Jiao Tong University
WebJun 1, 2024 · STING and IRF3 are required for spontaneous anti-tumor CD8+ T cell responses and control of tumor growth. Type I IFN production to tumor DNA in DC requires STING, cGAS and IRF3. Empty Cell: IRF3-/-Deng et al. (2014a) IFNAR-/-MC38 + radiation: Type I IFN sensing and STING are required for the anti-tumor effect or radiation. WebApr 4, 2024 · Aerobic glycolysis is a metabolic hallmark of activated DCs, but how the glycolytic pathway intersects with STING signaling in tumor-infiltrating DCs remains …
WebJun 10, 2010 · Toll-like receptor (TLR)–directed dendritic cell (DC) activation is critical for the tailoring of immune responses to specific pathogens. 1,2 TLR agonists initiate profound changes in DCs, which without undergoing cellular division transition from a resting state into an activated mature state. 3,4 This process involves large-scale changes in the … WebJan 11, 2024 · The mechanisms underlying oxidative stress-shaped DC antitumor function are elusive. Hu et al. show that DC-derived reactive oxygen species (ROS) trigger SENP3 accumulation and in turn promote …
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WebAug 15, 2024 · Glycolysis is a metabolic pathway and an anaerobic energy source that has evolved in nearly all types of organisms. Another name for the process is the Embden-Meyerhof pathway, in honor of the major … asian imperial lunenburg maWebApr 27, 2024 · Inflammatory cells switch their metabolism towards glycolysis to meet their high energetic and biosynthetic demand. Interestingly, metabolites that accumulate in glycolytic conditions have been described to reinforce the inflammatory response by modulating intracellular signalling pathways, remodelling the epigenetic landscape or … at45326benWebFeb 17, 2024 · Innate immune cells play the first line of defense against pathogens. Phagocytosis or invasion by pathogens can affect mitochondrial metabolism in macrophages by diverse mechanisms and shape the macrophage response (proinflammatory vs. immunomodulatory) against pathogens. Besides β-nicotinamide adenine dinucleotide 2' … at45026benWebImportantly, glycolysis facilitated STING-dependent DC activity in tissue samples from non-small cell lung cancer patients. Our results provide mechanistic insight into how the crosstalk of glycolytic metabolism and STING signaling enhances DC antitumor activity and can be harnessed to improve cancer therapies. asian imperial lunenburg massachusettsWebActivation of STING signaling in DCs promotes antitumor immunity. Aerobic glycolysis is a metabolic hallmark of activated DCs, but how the glycolytic pathway intersects with STING signaling in tumor-infiltrating DCs remains elusive. Here, we show that glycolysis drives STING signaling to facilitate DC-mediated antitumor immune responses. at45026ben partsWebMar 13, 2024 · Glycolysis is the process by which one molecule of glucose is converted into two molecules of pyruvate, two hydrogen ions and two molecules of water. Through this process, the 'high energy' intermediate molecules of ATP and NADH are synthesised. Pyruvate molecules then proceed to the link reaction, where acetyl-coA is produced. … at4033/seWebMay 14, 2024 · STING is a transmembrane protein that regulates DNA-mediated type I interferon-dependent innate immune responses [ 22 ]. During intracellular bacterial … at43-7251-dj