Megalin function
Web1 jan. 2013 · Megalin functions in a complex with the 460-kDa extracellular protein cubilin. Cubilin also binds several plasma proteins, including albumin, but depends on megalin for the endocytosis of cubilin–ligand complexes (19,20). Web31 mrt. 2015 · Besides the kidney, megalin is expressed in many absorptive epithelia, including the neuro-epithelium. There, megalin is thought to participate to RME-associated cell signaling. Failure to uptake ligands at a specific time and/or in a tissue-specific manner during fetal development may provoke the various clinical abnormalities observed in …
Megalin function
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Web1 dec. 2003 · Megalin was first identified by Kerjaschki and Farquhar and later found to be a member of the low-density lipoprotein receptor family, composed of a single-transmembrane domain, a large ectodomain, and a short cytoplasmic tail (10–12).Megalin mediates tubular uptake of low-molecular-weight proteins in the kidney and is also involved in the … LRP2/megalin functions to mediate endocytosis of ligands leading to degradation in lysosomes or transcytosis. LRP2/megalin can also form complexes with CUBAM , the cubilin and amnionless complex. Those complexes are able to reabsorb several molecules and can be inhibited by sodium maleate. Meer weergeven Low density lipoprotein receptor-related protein 2 also known as LRP-2 or megalin is a protein which in humans is encoded by the LRP2 gene. Meer weergeven LRP2 was identified as the antigen of rat experimental membranous nephropathy (Heyman nephritis) and originally named gp330 and subsequently megalin and later LRP2. LRP2/megalin is a multiligand binding receptor found in the plasma membrane of … Meer weergeven LRP2 has been shown to associate with the following proteins in the plasma membrane/cytosol of cells: • CUBAM, • DAB2, Meer weergeven Disfunction in the LRP2-mediated endocytic trafficking and endocytic capacity in the proximal tubule can result in low molecular weight proteinuria, which is a hallmark of many diseases. Mutations in the LRP2 gene are associated with Meer weergeven • Longoni M, Kantarci S, Donnai D, Pober BR (August 2008). "Donnai-Barrow Syndrome". In Adam MP, Mirzaa GM, Pagon RA, … Meer weergeven
Web23 mrt. 2024 · Megalin is a 600 kDa single transmembrane protein with a small intracellular tail and a large extracellular domain containing 4 ligand-binding regions, allowing it to bind >40 different ligands, including albumin. 9, 10 Megalin forms a 1:1 complex with the extracellular protein cubilin. WebMegalin is an endocytic receptor expressed on the apical surface of several epithelial cells that internalizes a variety of ligands including nutrients, hormones and their carrier …
WebLoss of megalin function that affects endocytic pathway integrity will also lead to urinary protein excretion (Weyer et al. 2011; Storm et al. 2013) (Fig. 3A). Additionally, ... Web1 apr. 2002 · Functions of cubilin and megalin The multiligand binding properties of both megalin and cubilin indicate a SCAVENGER RECEPTOR function, which mediates …
WebMegalin: A Novel Endocytic Receptor for Prorenin and Renin. Megalin is an endocytic receptor contributing to protein reabsorption. Impaired expression or trafficking of …
Webmegalin has a role in thyroid homeostasis with possible implications in thyroid diseases; a binding affinity of disabled homolog 2 mitogen-responsive phosphoprotein interaction … every song in scratchin melodiiWebNormal reabsorption of glomerular filtrate proteins probably requires recycling of the endocytic receptors megalin (gp330) and cubilin. Both receptors are located on the … brownsburg breakfastWeb1 apr. 2002 · Megalin is involved in the regulation of thyroid-hormone production by the thyroid gland by mediating uptake and transcytosis of thyroglobulin. The endocytic uptake of nephro- and ototoxic drugs,... every song in henry danger the musicalWebMegalin, a membrane-associated endocytic receptor, and its related proteins such as cubilin, the neonatal Fc receptor for IgG, and NaPi-IIa are important in receptors … brownsburg breakfast placesWeb23 jun. 2005 · Megalin is a multifunctional endocytic receptor that is expressed in renal proximal tubules and plays critical roles in the renal uptake of various proteins. It was hypothesized that megalin-dependent endocytosis might play a … brownsburg breaking newsWebThis study examined whether urinary C-megalin reflects renal function or albuminuria in diabetes. Methods: This was a cross-sectional study involving 1576 patients with type 1 … every song in the worldWeb11 jul. 2014 · Megalin plays a particular key role in the proximal tubular uptake of glomerular-filtered albumin and other low-molecular-weight-proteins. Consistent with this function, megalin knockout mice develop low-molecular-weight proteinuria and albuminuria [ … every song in hamilton