Web2 Mar 2024 · GSEA revealed the top 50 overexpressed genes in the TERT -H subgroup versus TERT -L, ranking from the largest to the smallest fold change in Fig. 2A. Both c-Myc and MYCN are known TERT transcriptional … Web25 Sep 2024 · Overexpression of TERT and telomere dysfunction is frequently detected in a variety of human cancer specimens, including thyroid cancer 10, bladder cancer 11, …
Telomerase reactivation induces progression of mouse Braf
Web9 Jun 2024 · Human telomerase reverse transcriptase ( TERT) gene promoter mutations have been observed in multiple types of malignant tumors [ 6 ]. It is believed that … Web25 Sep 2024 · Overexpression of TERT and telomere dysfunction is frequently detected in a variety of human cancer specimens, including thyroid cancer 10, bladder cancer 11, … merchandising processing fee 2021
Clinical importance of TERT overexpression in ... - Europe PMC
WebIn the present study, we aimed to examine the potential of telomerase reverse transcriptase (TERT), because TERT overexpression in skin activates resting hair follicle bulge stem cells, which triggers initiation of a new hair follicle growth phase and promotes hair synthesis. To this end, we screened polyphenols that activate TERT expression in ... Web17 Mar 2024 · Future studies will address whether the overexpression of either TERT or TERC alone will be able to induce transformation and tumorigenesis of HPV immortalized cervical epithelial cells. In addition, it will be important to determine whether the transforming activity of hTERT + TERC requires their canonical functions, telomerase … Web20 Feb 2024 · Conversely, the TERT KD-mediated inhibition of autophagy was rescued by HK2 overexpression , suggesting that HK2 is required for TERT-induced autophagy activation. To examine the involvement of mTOR in the TERT-HK2-autophagy axis, we assessed mTOR activity by examining phosphorylation of ribosomal protein S6 kinase … merchandising process in export house